ARTERIAL VASCULAR DISEASES

Abstract

Obliterating endarteritis ("endarteritis obliterans") is a progressive disease of the peripheral arterial blood vessels, accompanied by severe circulatory disorders, often with the development of gangrene as a result of thrombosis. The disease mainly affects the blood vessels of the legs, it occurs more often in men than in women. Etiology and pathogenesis. The etiology of the disease has not yet been determined, and there are many theories in this regard. The American surgeon L.B. Jurger put forward the inflammatory theory at the beginning of the 20th century. According to this theory, the occurrence of thromboses and thromboangiitis of peripheral arteries is associated with infections, changes in the chemical composition of the blood, and metabolic disorders. Later, it was found that the development of obliterating endarteritis is not always associated with inflammation. Hyperplasia and proliferation of the intima of the arteries can develop for unknown reasons, not related to inflammation.