THE IMPACT OF OBESITY-RELATED ESTROGEN CHANGES ON THE DEVELOPMENT OF BREAST AND ENDOMETRIAL CANCER

Authors

  • Mamajonov Khasan Ikramovich Mamajonov Khasan Ikramovich Author
  • Tursunova Nodira Isroilovna Tursunova Nodira Isroilovna Author
  • Abdinazarova Iltifotkhon Sodiqjon qizi Abdinazarova Iltifotkhon Sodiqjon qizi Author

Keywords:

Obesity; Estrogen; Aromatase; Breast Cancer; Endometrial Cancer; Hormonal Imbalance; Cancer Risk.

Abstract

This article examines the impact of obesity-related alterations in estrogen levels on the development and progression of breast and endometrial cancers. It highlights the biological mechanisms by which adipose tissue contributes to hormonal imbalance, increased aromatase activity, and chronic inflammation—factors that collectively elevate cancer risk. The paper also reviews current scientific findings on estrogen-dependent tumor growth and emphasizes the importance of preventive strategies targeting weight management and hormonal regulation.

Author Biographies

  • Mamajonov Khasan Ikramovich, Mamajonov Khasan Ikramovich

    Tashkent State Medical University,

    Department of Oncology, Pediatric

    Oncology and Palliative Care,

    PhD Associate Professor

  • Tursunova Nodira Isroilovna, Tursunova Nodira Isroilovna

    Tashkent State Medical University,

     Department of Oncology,

    Pediatric Oncology and Palliative Care,

    PhD Associate Professor

  • Abdinazarova Iltifotkhon Sodiqjon qizi, Abdinazarova Iltifotkhon Sodiqjon qizi

    Tashkent State Medical University,

    Department of Oncology,

    Pediatric Oncology and Palliative Care,

    PhD Senior Lecturer

References

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Published

2025-12-23

Issue

Vol. 1 No. 1 (2025): UNIVERSAL INSIGHTS CONFERENCE ON SCIENCE AND SOCIETY

Section

Articles