ANALYSIS OF AGE-RELATED MULTIPLEX CONFOCAL MORPHOMETRIC PARAMETERS OF THE MYOCARDIUM IN CHRONIC CORONARY HEART DISEASE

Authors

  • Botirov Doniyor Abdusaidovich Botirov Doniyor Abdusaidovich Author
  • Eshbaev Erkin Abdukhalimovich Eshbaev Erkin Abdukhalimovich Author

Keywords:

chronic ischemic heart disease, myocardium, sarcomeric actin, immunohistochemical expression

Abstract

Chronic coronary heart disease is one of the most common diseases with high mortality rates in the world, and its etiology and pathomorphological features still remain an urgent problem. Differences in risk factors in different countries and populations form specific morphological changes in the myocardium, which necessitates an in-depth study of the pathogenetic mechanisms and early morphological substrates of the disease. In a morphometric study, myocardial microarrays were digitized on a NanoZoomer scanner, and the resulting microimages were analyzed using the QuPath-0.5.0 and ImageJ programs. In chronic coronary heart disease, age-related growth of fibrous structures in the myocardial stroma was revealed, while their volume increased by an average of 4.41 times in the age groups of 18-44 years and 75-90 years.

Author Biographies

  • Botirov Doniyor Abdusaidovich, Botirov Doniyor Abdusaidovich

    independent candidate of the Samarkand State Medical University (Samarkand, Uzbekistan)

  • Eshbaev Erkin Abdukhalimovich, Eshbaev Erkin Abdukhalimovich

    DSc, Professor, Tashkent State Medical University (Tashkent, Uzbekistan)

References

Downloads

Published

2026-06-25

Issue

Vol. 7 No. 1 (2026): ADVANCES IN RESEARCH AND INNOVATION SOLUTIONS

Section

Articles