RISK FACTORS FOR RECURRENT PREGNANCY LOSS IN WOMEN WITH ANTIPHOSPHOLIPID SYNDROME

Abstract

Antiphospholipid syndrome (APS) is an autoimmune disorder characterized by the production of autoantibodies against phospholipids and phospholipid-binding proteins. During pregnancy, APS significantly increases the risk of adverse reproductive outcomes, including recurrent pregnancy loss, antenatal fetal death, and thromboembolic complications. Impaired placental circulation plays a central role in the pathogenesis of APS. Autoimmune-mediated thrombosis and endothelial damage affect the placental and trophoblastic vessels, leading to disruption of the uteroplacental blood flow, fetal hypoxia, antenatal fetal death, or spontaneous miscarriage in early pregnancy.