PROGNOSTIC SIGNIFICANCE OF MOLECULAR BIOLOGICAL MARKERS AND UROTHELIAL REGENERATION FEATURES IN NON-MUSCLE INVASIVE BLADDER CANCER

Authors

  • Babakulov Sh.Kh. Babakulov Sh.Kh. Author
  • Nishonov D.A. Nishonov D.A. Author
  • Navruzova V.S. Navruzova V.S. Author
  • Babakulova Sh.Kh. Babakulova Sh.Kh. Author

Keywords:

Non-muscle invasive bladder cancer (NMIBC), immunohistochemistry, Ki-67, p53, E-cadherin, prognosis, urothelial regeneration, Lactobacillus acidophilus, transurethral resection (TURBT).

Abstract

Despite the efficacy of transurethral resection (TURBT), the recurrence rate of non-muscle invasive bladder cancer (NMIBC) remains high (50–70%). Standard criteria, such as tumor stage and grade, do not always accurately reflect the biological potential of the tumor. This necessitates the search for additional molecular predictors and the evaluation of the intact urothelium state in the surgical intervention zone to optimize preventive therapy.

Author Biographies

  • Babakulov Sh.Kh., Babakulov Sh.Kh.

    Tashkent State Medical University, Tashkent, Uzbekistan

  • Nishonov D.A., Nishonov D.A.

    Tashkent State Medical University, Tashkent, Uzbekistan

  • Navruzova V.S., Navruzova V.S.

    Tashkent State Medical University, Tashkent, Uzbekistan

  • Babakulova Sh.Kh., Babakulova Sh.Kh.

    Tashkent State Medical University, Tashkent, Uzbekistan

References

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Published

2026-06-04

Issue

Vol. 7 No. 1 (2026): FRONTIERS OF KNOWLEDGE AND INTERDISCIPLINARY DISCOVERY

Section

Articles