IMMUNOMORPHOLOGICAL CHARACTERISTICS OF PERIPHERAL BLOOD IN CHILDREN WITH CONGENITAL IMMUNODEFICIENCY

Abstract

This thesis investigates the comprehensive immunomorphological profile of peripheral blood in pediatric patients diagnosed with congenital immunodeficiency disorders. The study employs advanced flow cytometric analysis, morphological examination, and quantitative assessment of cellular and humoral immune components to establish distinctive diagnostic patterns. Results demonstrate significant alterations in lymphocyte subpopulations, neutrophil morphology, and immunoglobulin levels that correlate with disease severity and clinical manifestations. The findings provide critical insights for early diagnosis, prognostic stratification, and personalized therapeutic interventions in this vulnerable population, contributing substantially to pediatric immunology and clinical hematology.