AUTOIMMUNE MECHANISMS OF MELANOCYTE DESTRUCTION IN VITILIGO - THE ROLE OF INTERFERON-GAMMA SIGNALING AND CD8+ T-CELL CYTOTOXICITY

Authors

  • Yokubov Farrukh Farhadovich Yokubov Farrukh Farhadovich Author

Keywords:

vitiligo, melanocyte autoimmunity, CD8+ cytotoxic lymphocytes, interferon-gamma, CXCL10, Janus kinase signaling, oxidative stress, melanocyte-specific antigens, autoimmune dermatosis, T-regulatory cell deficiency

Abstract

This study investigates the immunopathogenetic mechanisms underlying progressive melanocyte loss in vitiligo, with emphasis on the interferon-gamma-CXCL10 signaling axis and cytotoxic CD8+ T-lymphocyte activity. Through cytokine profiling, immunohistochemical tissue analysis, and flow cytometric peripheral blood assessment, the research delineates the sequential molecular events driving autoimmune melanocyte destruction and identifies targetable immunological checkpoints for therapeutic intervention.

Author Biography

  • Yokubov Farrukh Farhadovich, Yokubov Farrukh Farhadovich

    Fergana Medical Institute of Public Health

    Assistant of the Department of Dermatovenereology and Allergology

References

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Published

2026-05-06

Issue

Vol. 6 No. 1 (2026): GLOBAL RESEARCH AND ACADEMIC INNOVATIONS

Section

Articles