JANUS KINASE INHIBITORS AND ANTI-INTERLEUKIN-17 BIOLOGIC AGENTS IN PRIMARY CICATRICIAL ALOPECIA - CLINICAL EFFICACY AND IMMUNOLOGICAL RESPONSE ASSESSMENT

Authors

  • Abduvaliyev Begali Sherali ugli Abduvaliyev Begali Sherali ugli Author

Keywords:

cicatricial alopecia, lichen planopilaris, frontal fibrosing alopecia, Janus kinase inhibitors, interleukin-17 blockade, perifollicular fibrosis, trichoscopy, follicular unit scarring, biologic therapy, Lichen Planopilaris Activity Index

Abstract

This study evaluates the clinical efficacy and immunohistochemical response of targeted biologic therapies - specifically Janus kinase inhibitors and anti-interleukin-17 monoclonal antibodies - in patients with primary lymphocytic cicatricial alopecia, including lichen planopilaris and frontal fibrosing alopecia. Through trichoscopic monitoring, scalp biopsy transcriptomic analysis, and validated clinical scoring, the research demonstrates meaningful suppression of perifollicular inflammation and stabilization of fibrotic progression under biologic intervention.

Author Biography

  • Abduvaliyev Begali Sherali ugli, Abduvaliyev Begali Sherali ugli

    Fergana Medical Institute of Public Health

    Assistant of the Department of Dermatovenereology and Allergology

References

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Published

2026-05-06

Issue

Vol. 6 No. 1 (2026): GLOBAL RESEARCH AND ACADEMIC INNOVATIONS

Section

Articles