MOLECULAR-GENETIC AND IMAGING MARKERS OF CARDIOVASCULAR REMODELING IN ISCHEMIC HEART DISEASE AND OBESITY

Abstract

Ischemic heart disease (IHD) combined with obesity accelerates adverse myocardial remodeling through mechanisms involving visceral adiposity, systemic inflammation, and endothelial dysfunction. Epicardial adipose tissue (EAT) acts as a metabolically active visceral depot with local paracrine effects on the myocardium. Genetic polymorphisms in IL6, ZNF648, and ADIPOQ may influence inflammatory signaling, endothelial integrity, and adipokine-mediated cardioprotection, contributing to subclinical myocardial dysfunction.