IMPROVING EARLY DIAGNOSIS AND PROGNOSIS OF CHRONIC HEPATITIS C BASED ON THE ASSESSMENT OF IL-10 (G108A) AND TNF-α (G308A) GENE POLYMORPHISMS

Abstract

This article demonstrates that IL-10 (−1082 G/A) and TNF-α (−308 G/A) gene polymorphisms are significantly associated with susceptibility to chronic viral hepatitis C and its progression. The analysis showed that for both genes, the AA genotype and A allele were significantly more frequent in patients compared to the control group, confirming their role as risk factors for the development of chronic viral hepatitis C. Conversely, the GG genotype and G allele were more common in the control group, indicating their protective effect against the disease. Additionally, the genotype distributions of IL-10 and TNF-α in both patients and controls were in accordance with Hardy–Weinberg equilibrium, supporting the genetic representativeness of the study sample.