SKIN BARRIER DYSFUNCTION AND IMMUNE INFLAMMATORY FACTORS IN CHILDREN WITH ATOPIC DERMATITIS

Authors

  • Muslimov Ganijon Inotullayevich Muslimov Ganijon Inotullayevich Author

Keywords:

atopic dermatitis, epidermal barrier, filaggrin mutation, trans-epidermal water loss, T-helper cells, interleukin-4, interleukin-13, Th2 polarization, ceramides, inflammatory cytokines.

Abstract

This research provides comprehensive analysis of the interrelationship between skin barrier disruption and immune inflammatory processes in the pathogenesis of atopic dermatitis. The study examines molecular defects in epidermal barrier structure, filaggrin mutations, trans-epidermal water loss, T-helper cell polarization, and cytokine network dysregulation. The findings establish a fundamental foundation for developing pathogenetically grounded therapeutic strategies.

Author Biography

  • Muslimov Ganijon Inotullayevich, Muslimov Ganijon Inotullayevich

    Assistant of Fergana Medical Institute of Public Health

References

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Published

2025-12-31

Issue

Vol. 2 No. 1 (2026): GLOBAL RESEARCH AND ACADEMIC INNOVATIONS

Section

Articles