THE PATHOGENETIC SIGNIFICANCE OF SKIN BARRIER DYSFUNCTION IN ATOPIC DERMATITIS

Authors

  • Ashurov Dilshod Davlatovich Ashurov Dilshod Davlatovich Author
  • Shivam Mishra Shivam Mishra Author

Keywords:

atopic dermatitis, filaggrin, transepidermal water loss, ceramides, tight junctions, stratum corneum, barrier function, inflammation, sensitization, therapeutic moisturizers.

Abstract

This thesis investigates the fundamental role of epidermal barrier impairment in atopic dermatitis pathogenesis, integrating genetic, immunological, and environmental factors. The study analyzes filaggrin deficiency, lipid abnormalities, and their contribution to disease chronicity. Results establish that barrier restoration through targeted emollient therapy combined with anti-inflammatory treatment provides optimal disease control and reduces exacerbation frequency.

Author Biographies

  • Ashurov Dilshod Davlatovich, Ashurov Dilshod Davlatovich

    Senior teacher of the Fergana Medical Institute of Public Health

  • Shivam Mishra, Shivam Mishra

    Student of the Fergana Medical Institute of Public Health

References

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Published

2025-12-31

Issue

Vol. 2 No. 1 (2025): GLOBAL TRENDS IN SCIENCE AND INNOVATION

Section

Articles