THE ROLE OF INSULIN RESISTANCE IN OBESITY DEVELOPMENT IN ADOLESCENTS

Authors

  • Saidjalilova Dilnoza Djavdatovna Saidjalilova Dilnoza Djavdatovna Author
  • G‘ulomova Ra’noxon Islomjonovna G‘ulomova Ra’noxon Islomjonovna Author

Keywords:

adolescent obesity, insulin resistance, adipose tissue, leptin, adiponectin, pro-inflammatory cytokines, metabolic syndrome, hyperglycemia, hyperinsulinemia.

Abstract

This research provides comprehensive analysis of the molecular-biological mechanisms, metabolic consequences, and clinical significance of insulin resistance in the pathogenesis of adolescent obesity. The study examines adipose tissue dysfunction, pro-inflammatory cytokines, adipokine imbalance, glucose homeostasis disruption, metabolic syndrome components, and pathogenetically grounded therapeutic strategies. The findings establish a foundation for preventing diabetes mellitus and cardiovascular diseases.

Author Biographies

  • Saidjalilova Dilnoza Djavdatovna, Saidjalilova Dilnoza Djavdatovna

    Toshkent davlat tibbiyot universiteti “1-Akusherlik va

     ginekologiya” kafedrasi professori, DSc

  • G‘ulomova Ra’noxon Islomjonovna, G‘ulomova Ra’noxon Islomjonovna

    Assistant of Fergana Medical Institute of Public Health

References

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Published

2025-12-31

Issue

Vol. 2 No. 1 (2025): GLOBAL TRENDS IN SCIENCE AND INNOVATION

Section

Articles