PATHOPHYSIOLOGICAL BASIS OF AUTOIMMUNE PROCESSES IN VITILIGO

Abstract

This thesis examines the autoimmune mechanisms underlying melanocyte destruction in vitiligo, integrating genetic susceptibility, oxidative stress, and immune dysregulation. The work analyzes the role of cytotoxic T lymphocytes, autoantibodies, and innate immunity in disease pathogenesis. Results demonstrate that vitiligo represents a complex autoimmune disorder requiring multimodal therapeutic approaches targeting both immune activation and melanocyte protection for optimal repigmentation.