NEONATAL AND INFANTILE VESICULOPUSTULAR DERMATOSES - CLINICAL CRITERIA AND DIFFERENTIAL DIAGNOSTIC APPROACH TO INFECTIOUS, IMMUNOLOGICAL, AND GENETIC ETIOLOGIES IN PEDIATRIC PRACTICE

Abstract

This study establishes a structured clinical, microbiological, and immunohistochemical differential diagnostic framework for vesiculopustular dermatoses presenting in the neonatal and early infantile period, differentiating infectious etiologies including staphylococcal scalded skin syndrome and bullous impetigo from immunologically mediated disorders such as neonatal pemphigus and incontinentia pigmenti. Through systematic lesion morphology analysis, bacterial culture, direct immunofluorescence, and genetic testing, the research defines discriminating diagnostic criteria applicable in acute pediatric clinical settings.