THYMIC STROMAL LYMPHOPOIETIN-MEDIATED EPITHELIAL ALARMIN SIGNALING AND SKIN-IMMUNE AXIS CROSSTALK IN THE PATHOGENESIS OF PEDIATRIC ATOPIC DERMATITIS

Authors

  • Sobirjonova Shakhzodakhon Gʻofforjon qizi Sobirjonova Shakhzodakhon Gʻofforjon qizi Author

Keywords:

thymic stromal lymphopoietin, interleukin-33, interleukin-25, alarmin cytokines, epithelial barrier signaling, type 2 innate lymphoid cells, dendritic cell polarization, skin-immune axis, pediatric inflammation, Th2 amplification.

Abstract

This investigation examines the role of epithelial-derived alarmin cytokines - thymic stromal lymphopoietin, interleukin-25, and interleukin-33 - in orchestrating the skin-immune axis dysregulation that underlies pediatric atopic dermatitis pathogenesis. Through immunohistochemical quantification of alarmin expression, dendritic cell subset characterization, and mechanistic correlation with clinical severity indices, the study establishes alarmin-driven innate immune activation as the critical upstream amplifier connecting barrier dysfunction to adaptive Th2 inflammation in children.

Author Biography

  • Sobirjonova Shakhzodakhon Gʻofforjon qizi, Sobirjonova Shakhzodakhon Gʻofforjon qizi

    Fergana Medical Institute of Public Health

    Assistant of the Department of Dermatovenereology and Allergology

References

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Published

2026-05-19

Issue

Vol. 6 No. 2 (2026): SYMPOSIUM ON ADVANCED STUDIES AND FUTURE DIRECTIONS

Section

Articles