ENDOMETRIAL HISTOPATHOLOGY IN WOMEN WITH RECURRENT PREGNANCY LOSS AND ANTIPHOSPHOLIPID SYNDROME

Abstract

Antiphospholipid syndrome (APS) is one of the leading causes of recurrent pregnancy loss, inducing morphological and functional alterations in the endometrium that impair embryo implantation and early pregnancy development. This article analyzes the histological characteristics of the endometrium in women with recurrent pregnancy loss associated with APS. The findings demonstrated that the most common histological changes included inadequate decidualization, stromal fibrosis and edema, microcirculatory disturbances, vascular thrombosis, inflammatory cell infiltration, and structural alterations of the endometrial glands. These histological abnormalities indicate reduced endometrial receptivity and play a significant role in the pathogenesis of recurrent reproductive loss in women with antiphospholipid syndrome.